Publications

  • Identifying novel gene dysregulation associated with opioid overdose death: A meta-analysis of differential gene expression in human prefrontal cortex. Carter et al., doi:10.1101/2024.01.12.24301153.
  • Three-dimensional characterization of medium spiny neuron heterogeneity in the adult mouse striatum. Gayden et al., doi:10.1101/2023.05.04.539488.
  • Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration. Buck et al., doi:10.1101/2023.10.02.560584.
  • Consideration of genetic and sex effects in mice enhances consilience with human addiction studies. Saul et al., doi:10.1101/2020.02.14.949784.

2024

Single nuclei transcriptomics in human and non-human primate striatum in opioid use Disorder

BaDoi N Phan, Madelyn H Ray, Xiangning Sue, Chen Fu, Robert J Fenster, Stephen J Kohut, Jack Bergman, Suzanne N Haber, Kenneth M McCullough, Madeline K Fish, Jill R. Glausier, Qiao Su, Allison E Tipton, David A. Lewis, Zachary Freyberg, George C. Tseng, Shelley J Russek, Yuriy Alekseyev, Kerry J. Ressler, Marianne L. Seney, Andreas R. Pfenning, Ryan W. Logan

2023

Central insulin Dysregulation in antipsychotic-naive First-episode Psychosis: in Silico exploration of gene expression signatures

Jiwon Lee, Xiangning Xue, Emily Au, William B. McIntyre, Roshanak Asgariroozbehani, George C. Tseng, Maria Papoulias, Kristoffer Pangaiban, Sri Mahavir Agarwal, Robert Mcculumsmith, Zachary Freyberg, Ryan W. Logan, Margaret Hahn

Circadian rhythm disruptions associated with opioid use disorder in synaptic proteomes of human dorsolateral prefrontal cortex and nucleus accumbens

Stephanie Puig, Xiangning Xue, Ryan Salisbury, Micah A Shelton, Sam-Moon Kim, Mariah A Hildebrand, Jill R Glausier, Zachary Freyberg, George C Tseng, Anastasia K Yocum, David A Lewis, Marianne L Seney, Matthew L MacDonald, Ryan W Logan

Traumatic Brain Injury–Induced Fear Generalization in Mice Involves Hippocampal Memory Trace Dysfunction and Is Alleviated by (R,S)-Ketamine

Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-González, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, and Christine A. Denny

Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome

Kyle D. Ketchesin, Darius D. Becker-Krail, Xiangning Xue, Rashaun S. Wilson, TuKiet T. Lam, Kenneth R. Williams, Angus C. Nairn, George C. Tseng, and Ryan W. Logan

DiffCircaPipeline: A Framework For Multifaceted Characterization Of Differential Rhythmicity

Xiangning Xue, Wei Zong, Zhiguang Huo, Kyle D. Ketchesin, Madeline R. Scott, Kaitlyn A. Petersen, Ryan W. Logan, Marianne L. Seney, Colleen McClung, and George Tseng

2022

Editorial: Neuroinflammation, metabolism, and psychiatric disorders

Zachary Freyberg, Marion Leboyer, Brenda WJH Penninx, and Ryan W. Logan

Brain region- and sex-specific transcriptional profiles of microglia

Kelly Barko, Micah Shelton, Xiangning Xue, Yvette Afriyie-Agyemang, Stephanie Puig, Zachary Freyberg, George C. Tseng, Ryan W. Logan and Marianne L. Seney

Sex-specific role of the circadian transcription factor NPAS2 in opioid tolerance, withdrawal and analgesia

Stephanie Puig, Micah A. Shelton, Kelly Barko, Marianne L. Seney, and Ryan W. Logan

Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine

Despoina Aslanoglou, Suzanne Bertera, Laura Friggeri, ..., David R. Sibley, Rita Bottino, and Zachary Freyberg

A role for the circadian transcription factor NPAS2 in the progressive loss of non‐rapid eye movement sleep and increased arousal during fentanyl withdrawal in male mice

Mackenzie C. Gamble, Byron Chuan, Teresa Gallego‐Martin, Micah A. Shelton, Stephanie Puig, Christopher P. O’Donnell, and Ryan W. Logan

A Glitch in the Matrix: The Role of Extracellular Matrix Remodeling in Opioid Use Disorder

Madelyn H. Ray, Benjamin R. Williams, Madeline K. Kuppe, Camron D. Bryant and Ryan W. Logan

Relevance of interactions between dopamine and glutamate neurotransmission in schizophrenia

Silas A. Buck, M. Quincy Erickson-Oberg, Ryan W. Logan, and Zachary Freyberg

Astrocyte Molecular Clock Function in the Nucleus Accumbens Is Important for Reward-Related Behavior

Darius D. Becker-Krail, Kyle D. Ketchesin, Jennifer N. Burns, Wei Zong, Mariah A. Hildebrand, Lauren M. DePoy, Chelsea A. Vadnie, George C. Tseng, Ryan W. Logan, Yanhua H. Huang, and Colleen A. McClung

Molecular rhythm alterations in prefrontal cortex and nucleus accumbens associated with opioid use disorder

Xiangning Xue, Wei Zong, Jill R. Glausier, Sam-Moon Kim, Micah A. Shelton, BaDoi N. Phan, Chaitanya Srinivasan, Andreas R. Pfenning, George C. Tseng, David A. Lewis, Marianne L. Seney, and Ryan W. Logan

The Suprachiasmatic Nucleus Regulates Anxiety-Like Behavior in Mice

Chelsea A. Vadnie, Kaitlyn A. Petersen, Lauren A. Eberhardt, Mariah A. Hildebrand, Allison J. Cerwensky, Hui Zhang, Jennifer N. Burns, Darius D. Becker-Krail, Lauren M. DePoy, Ryan W. Logan, and Colleen A. McClung

Circadian Transcription Factor NPAS2 and the NAD+-Dependent Deacetylase SIRT1 Interact in the Mouse Nucleus Accumbens and Regulate Reward

Darius D. Becker-Krail, Puja K. Parekh, Kyle D. Ketchesin, Shintaro Yamaguchi, Jun Yoshino, Mariah A. Hildebrand, Brandon Dunham, Madhavi K. Ganapathiraiu, Ryan W. Logan, and Colleen A. McClung

Sex differences in molecular rhythms in the human cortex

Ryan W. Logan, Xiangning Xue, Kyle D. Ketchesin, Gabriel Hoffman, Panos Roussos, George Tseng, Colleen A. McClung, and Marianne L. Seney

2021

Sex Differences in Behavioral and Brainstem Transcriptomic Neuroadaptations following Neonatal Opioid Exposure in Outbred Mice

Kristyn N. Borrelli, Emily J. Yao, William W. Yen, Rhushikesh A. Phadke, Qiu T. Ruan, Melanie M. Chen, Julia C. Kelliher, Carly R. Langan, Julia L. Scotellaro, Richard K. Babbs, Jacob C. Beierle, Ryan W. Logan, William Evan Johnson, Elisha M. Wachman, Alberto Cruz-Martín, and Camron D. Bryant

Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use disorder

Marianne L. Seney, Sam-Moon Kim, Jill R. Glausier, Mariah A. Hildebrand, Xiangning Xue, Wei Zong, Jiebiao Wang, Micah A. Shelton, BaDoi N. Phan, Chaitanya Srinivasan, Andreas R. Pfenning, George C. Tseng, David A. Lewis, Zachary Freyberg, and Ryan W. Logan

Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration

Silas A. Buck, Thomas Steinkellner, Despoina Aslanoglou, Michael Villeneuve, Sai H. Bhatte, Victoria C. Childers, Sophie A. Rubin, Briana R. De Miranda, Emma I. O'Leary, Elizabeth G. Neureiter, Keri J. Fogle, Michael J. Palladino, Ryan W. Logan, Jill R. Glausier, Kenneth N. Fish, David A. Lewis, J. Timothy Greenamyre, Brian D. McCabe, Claire E. J. Cheetham, Thomas S. Hnasko, and Zachary Freyberg

VGLUT2 Is a Determinant of Dopamine Neuron Resilience in a Rotenone Model of Dopamine Neurodegeneration

Silas A. Buck, Briana R. De Miranda, Ryan W. Logan, Kenneth N. Fish, J. Timothy Greenamyre, and Zachary Freyberg

Experimentally-imposed circadian Misalignment Alters the neural response to monetary rewards And response inhibition in healthy adolescents

Brant P. Hasler, Adriane M. Soehner, Meredith L. Wallace, Ryan W. Logan, Wambui Ngari, Erika E. Forbes, Daniel J. Buysse, and Duncan B. Clark

Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors

Despoina Aslanoglou, Suzanne Bertera , Marta Sánchez-Soto, R. Benjamin Free, Jeongkyung Lee, Wei Zong, Xiangning Xue, Shristi Shrestha, Marcela Brissova, Ryan W. Logan, Claes B. Wollheim, Massimo Trucco, Vijay K. Yechoor, David R. Sibley, Rita Bottino, and Zachary Freyberg

High‐throughput measurement of fibroblast rhythms reveals genetic heritability of circadian phenotypes in diversity outbred mice and their founder strains

Sam‐Moon Kim, Chelsea A. Vadnie, Vivek M. Philip, Leona H. Gagnon, Kodavali V. Chowdari, Elissa J. Chesler, Colleen A. McClung* and Ryan W. Logan*

Roles of inflammation in intrinsic pathophysiology and antipsychotic drug-induced metabolic disturbances of schizophrenia

Tyler R. Prestwood, Roshanak Asgariroozbehani, Sally Wu, Sri Mahavir Agarwal, Ryan W. Logan, Jacob S. Ballon, Margaret K. Hahn, and Zachary Freyberg

Circadian-Dependent and Sex-Dependent Increases in Intravenous Cocaine Self-Administration in Npas2 Mutant Mice

Lauren M. DePoy, Darius D. Becker-Krail, Wei Zong, Kaitlyn Petersen, Neha M. Shah, Jessica H. Brandon, Alyssa M. Miguelino, George C. Tseng, Ryan W. Logan, and Colleen A. McClung

Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2

Ryan W. Logan, Angela R. Ozburn, Rachel N. Arey, Kyle D. Ketchesin, Alicia Winquist, Andrew Crain, Brian T. D. Tobe, Darius Becker-Krail, Matthew B. Jarpe, Xiangning Xue, Wei Zong, Zhiguang Huo, Puja K. Parekh, Xiyu Zhu, Ethan Fitzgerald, Hui Zhang, Jeffrey Oliver-Smith, Lauren M. DePoy, Mariah A. Hildebrand, Evan Y. Snyder, George C. Tseng, and Colleen A. McClung

Critical roles for developmental hormones and genetic sex in stress-induced transcriptional changes associated with depression

Marianne L. Seney and Ryan W. Logan

Roles of dopamine and glutamate Co-release in the nucleus accumbens in mediating the actions of drugs of abuse

Silas A. Buck, Mary M. Torregrossa, Ryan W. Logan, and Zachary Freyberg

2020

Substrain specific behavioral responses in male C57BL/6N and C57BL/6J mice to a shortened 21-hour day and high-fat diet

Marissa J. Maroni, Kimberly M. Capri, Nicole L. Arruda, Rachel R. Gelineau, Hannah V. Deane, Holly A. Concepcion, Holly DeCourcey, Isabella K. Monteiro De Pina, Alexis V. Cushman, Madison H. Chasse, Ryan W. Logan, and Joseph A. Seggio

Sex differences in adult mood and in stress-induced transcriptional coherence across mesocorticolimbic circuitry

William Paden, Kelly Barko, Rachel Puralewski, Kelly M. Cahill, Zhiguang Huo, Micah A. Shelton, George C. Tseng, Ryan W. Logan and Marianne L. Seney

Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis

Udita Datta, Sarah E. Schoenrock, Jason A. Bubier, Molly A. Bogue, James D. Jentsch, Ryan W. Logan, Lisa M. Tarantino, and Elissa J. Chesler

Characterization of genetically complex Collaborative Cross mouse strains that model divergent locomotor activating and reinforcing properties of cocaine

Sarah A Schoenrock, Padam Kumar, Alexander Gomez-A, Price E Dickson, Sam- Moon Kim, Lauren Bailey, Sofia Neira, Kyle D Riker, Joseph Farrington, Christiann H Gaines, Saad Khan, Troy D Wilcox, Tyler A Roy, Michael R Leonardo, Ashley A Olson, Leona H. Gagnon, Vivek M Philip, William Valdar, Fernando Pardo-Manuel de Villena, James D Jentsch, Ryan W Logan, Colleen A McClung, Donita L Robinson, Elissa J Chesler, and Lisa M Tarantino

2019

Male C57BL6/N and C57BL6/J Mice Respond Differently to Constant Light and Running-Wheel Access

Kimberly M. Capri, Marissa J. Maroni, Hannah V. Deane, Holly A. Concepcion, Holly DeCourcey, Ryan W. Logan, and Joseph A. Seggio

Adapting Social Defeat Stress for Female Mice Using Species-Typical Interfemale Aggression

Ryan W. Logan

NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward

Ryan W. Logan, Puja K. Parekh, Gabrielle Kaplan, Darius Becker-Krail, Wilbur Williams III, Shintaro Yamaguchi, Jun Yoshino, Micah A. Shelton, Xiyu Zhu, Hui Zhang, Spencer Waplinger, Ethan Fitzgerald, Jeffrey Oliver-Smith, Poornima Sundarvelu, John F. Enwright III, Yanhua H. Huang, and Colleen A. McClung

Diurnal rhythms in gene expression in the prefrontal cortex in schizophrenia

Marianne L. Seney, Kelly Cahill, John F. Enwright III, Ryan W. Logan, Zhiguang Huo, Wei Zong, George Tseng, and Colleen A. McClung

Sex-Specific Effects of Stress on Mood-Related Gene Expression

Kelly Barko, William Paden, Kelly M. Cahill, Marianne L. Seney, and Ryan W. Logan

Cell type-specific regulation of nucleus accumbens synaptic plasticity and cocaine reward sensitivity by the circadian protein, nPAS2

Puja K. Parekh, Ryan W. Logan, Kyle D. Ketchesin, Darius Becker-Krail, Micah A. Shelton, Mariah A. Hildebrand, Kelly Barko, Yanhua H. Huang, and Colleen A. McClung

2018

Improved identification of concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap approach

Kelly M. Cahill, Zhiguang Huo, George C. Tseng, Ryan W. Logan, and Marianne L. Seney

The Intertwined Roles of Circadian Rhythms and Neuronal Metabolism Fueling Drug Reward and Addiction

Zachary Freyberg and Ryan W. Logan

Impact of sleep and circadian rhythms on addiction vulnerability in adolescents

Ryan W. Logan, Brant P. Hasler, Erika E. Forbes, Peter L. Franzen, Mary M. Torregrossa, Yanhua H. Huang, Daniel J. Buysse, Duncan B. Clark, and Colleen A. McClung

Pharmacogenetic manipulation of the nucleus accumbens alters binge-like alcohol drinking in mice

Kush Purohit, Puja K. Parekh, Joseph Kern, Ryan W. Logan, Zheng Liu, Yanhua Huang, Colleen A. McClung, John C. Crabb, and Angela R. Ozburn

Opposite molecular signatures of depression in men and women

Marianne L. Seney, Zhiguang Huo, Kelly Cahill, Leon French, Rachel Puralewski, Joyce Zhang, Ryan W. Logan, George Tseng, David A. Lewis, and Etienne Sibille

Cocaine self-administration alters transcriptome-wide responses in the brain’s reward circuitry

Deena M. Walker, Hannah M. Cates, Yong-Hwee E. Loh, Immanuel Purushothaman, Aarthi Ramakrishnan, Kelly M. Cahill, Casey K. Lardner, Arthur Godino, Hope G. Kronman, Jacqui Rabkin, Zachary S. Lorsch, Philipp Mews, Marie A. Doyle, Jian Feng, Benoit Labonté, Ja Wook Koo, Rosemary C. Bagot, Ryan W. Logan, Marianne L. Seney, Erin S. Calipari, Li Shen, and Eric J. Nestler

2017

Neural Mechanisms of Circadian Regulation of Natural and Drug Reward

Lauren M. DePoy, Colleen A. McClung, and Ryan W. Logan

NPAS2 Regulation of Anxiety-Like Behavior and GABAA Receptors

Angela R. Ozburn*, Joseph Kern, Puja K. Parekh, Ryan W. Logan, Zheng Liu, Edgardo Falcon, Darius Becker-Krail, Kush Purohit, Nicole M. Edgar, Yanhua Huang, and Colleen A. McClung

Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis

Brian T. D. Tobe,, Andrew M. Crain, Alicia M. Winquist, Barbara Calabrese, Hiroko Makihara, Wen-ning Zhao, Jasmin Lalonde, Haruko Nakamura, Glenn Konopaske, Michelle Sidor, Cameron D. Pernia, Naoya Yamashita, Moyuka Wada, Yuuka Inoue, Fumio Nakamura, Steven D. Sheridan, Ryan W. Logan, Michael Brandel, Dongmei Wu, Joshua Hunsberger, Laurel Dorsett, Cordulla Duerr, Ranor C. B. Basa, Michael J. McCarthy, Namrata D. Udeshi, Philipp Mertins, Steven A. Carr, Guy A. Rouleau, Lina Mastrangelo, Jianxue Li, Gustavo J. Gutierrez, Laurence M. Brill, Nikolaos Venizelos, Guang Chen, Jeffrey S. Nye, Husseini Manji, Jeffrey H. Price, Colleen A. McClung, Hagop S. Akiskal, Martin Alda, De-Maw M. Chuang, Joseph T. Coyle Yang Liu, Yang D. Teng, Toshio Ohshima, Katsuhiko Mikoshiba, Richard L. Sidman, Shelley Halpain, Stephen J. Haggarty, Yoshio Goshima, and Evan Y. Snyder

2016

Circadian rhythms and metabolism: from the brain to the gut and back again

Matthew R. Cribbet, Ryan W. Logan, Mathew D. Edwards, Erin Hanlon, Clara Bien Peek, Jeremy J. Stubblefield, Sridhar Vasudevan, Fiona Ritchey, and Ellen Frank

Animal Models Of BipolarI Mania: The Past, Present And Future

Ryan W. Logan and Colleen A. McClung

Effects of aging on circadian patterns of gene expression in the human prefrontal cortex

Cho-Yi Chen, Ryan W. Logan, Tianzhou Ma, David A. Lewis, George C. Tseng, Etienne Sibille, and Colleen A. McClung

Long-term wheel-running and acute 6-h advances alter glucose tolerance and insulin levels in tALLYHO/JngJ mice

Nara F. Nascimento, Jasmin A. Hicks, Karen N. Carlson, Aikaterini Hatzidis, Danielle N. Amaral, Ryan W. Logan, and Joseph A. Seggio

2015

β-endorphin neuronal transplantation into the hypothalamus alters anxiety-like behaviors in prenatal alcohol exposed rats and non-preferring and preferring rats

Ryan W. Logan, Olivia Wynne, George Maglakelidze, Changqing Zhang, Stephanie O’Connell, Nadka I. Boyadjieva, and Dipak K. Sarkar

Chronic stress induces brain region specific alterations of molecular rhythms in mice that correlate with depression-like behavior

Ryan W. Logan, Nicole Edgar, Andrea G. Gillman, Daniel Hoffman, Xiyu Zhu, and Colleen A. McClung

2014

Circadian Rhythms and Addiction: Mechanistic Insights and Future Directions

Ryan W. Logan, Wilbur P. Williams III, and Colleen A. McClung

2013

Evidence for Possible Period 2 Gene Mediation of the Effects of Alcohol Exposure During the Postnatal Period on Genes Associated with Maintaining Metabolic Signaling in the Mouse Hypothalamus

Maria A. Agapito, Jacklin C. Barreira, Ryan W. Logan, and Dipak K. Sarkar

Altered Circadian Expression of Cytokines and Cytolytic Factors in Splenic Natural Killer Cells of Per1 - / - Mutant Mice

Ryan W. Logan, Olivia Wynne, Dale Levitt, Debbi Price, and Dipak K. Sarkar

High-precision genetic mapping of behavioral traits in the diversity outbred mouse population

R. W. Logan, R. F. Robledo1, J. M. Recla, V. M. Philip, J. A. Bubier, J. J. Jay, C. Harwood, T. Wilcox, D. M. Gatti, C. J. Bult, G. A. Churchill, and E. J. Chesler

Genetic variation of the natural killer gene complex has a role in lung cancer susceptibility

Ryan W. Logan and Dipak K. Sarkar

2012

Opportunities for Bioinformatics in the Classification of Behavior and Psychiatric Disorders

Elissa J. Chesler and Ryan W. Logan

Effects of Withdrawal from Chronic Intermittent Ethanol Vapor on the Level and Circadian Periodicity of Running-Wheel Activity in C57BL⁄6J and C3H⁄HeJ Mice

Ryan W. Logan, Walter D. McCulley III, Joseph A. Seggio, and Alan M. Rosenwasser

Circadian nature of immune function

Ryan W. Logan and Dipak K. Sarkar

Chronic Shift-Lag Alters the Circadian Clock of NK Cells and Promotes Lung Cancer Growth in Rats

Ryan W. Logan, Changqing Zhang, Sengottuvelan Murugan, Stephanie O’Connell, Dale Levitt, Alan M. Rosenwasser, and Dipak K. Sarkar

2011

Role of sympathetic nervous system in the entrainment of circadian natural-killer cell function

Ryan W. Logan, Alvaro Arjona, and Dipak K. Sarkar

2010

Circadian wheel-running activity during withdrawal from chronic intermittent ethanol exposure in mice

Ryan W. Logan, Joseph A. Seggio, Stacy L. Robinson, Gregory R. Richard, and Alan M. Rosenwasser

2009

Chronic Ethanol Intake Alters Circadian Phase Shifting and Free-Running Period in Mice

Joseph A. Seggio, Michael C. Fixaris, Jeffrey D. Reed, Ryan W. Logan, and Alan M. Rosenwasser

2007

Chronic ethanol intake modulates photic and non-photic circadian phase responses in the Syrian hamster

Joseph A. Seggio, Ryan W. Logan, Alan M. Rosenwasser

2005

Chronic Ethanol Intake Alters Circadian Period-Responses To Brief Light Pulses In Rats

Alan M. Rosenwasser, Ryan W. Logan, and Matthew E. Fecteau

Effects of ethanol intake and ethanol withdrawal on free-running circadian activity rhythms in rats

Alan M. Rosenwasser, Matthew E. Fecteau, and Ryan W. Logan

Circadian activity rhythms in selectively bred ethanol-preferring and nonpreferring rats

Alan M. Rosenwasser, Matthew E. Fecteau, Ryan W. Logan, Jeffrey D. Reed, Shawnia J. N. Cotter, and Joseph A. Seggio